What Questions to Ask Before Joining a Clinical Trial

Because You Deserve to Know Exactly What You’re Saying Yes To​

Joining a clinical trial is a big decision. You may be hopeful. You may be nervous. You may not be sure what questions to ask — or even if you’re allowed to ask them.

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Let’s clear that up: You’re not just allowed — you’re encouraged.

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A truly patient-centered clinical trial should welcome your questions. In fact, if you don’t get clear, honest answers, that’s a red flag. You’re not “just a participant.” You’re a partner. And partners ask questions.

Every clinical trial has a purpose — and you deserve to know what it is. Start with these:

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What is the goal of this trial?​

What condition or problem is it trying to address?​

How is this treatment or approach different from current options?​

Has this treatment been tested before? If so, what were the results?

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Understanding the “why” behind the research helps you decide if it’s aligned with your goals, values, and comfort level.

Some trials require multiple visits, tests, or even lifestyle changes. It’s okay to ask exactly what’s involved. For example:

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How long will the trial last?​

How often will I need to come in — and for how long each time?​

Can any visits be done remotely or from home?​

Will I need to stop taking any current medications?​

What happens if I want to leave the study early?

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You should never feel trapped or surprised. Good research respects your time and your right to say “no” at any point.

All research comes with some level of uncertainty. You should be told what’s known — and what isn’t.

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Ask:​

What are the known side effects or risks?​

What side effects might happen, even if they’re rare?​

What happens if I experience a problem during the trial?​

Is there a plan for medical care if something goes wrong?​

Who covers the cost if I need extra treatment due to the study?

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Real transparency means hearing both the benefits and the risks — clearly, honestly, and without pressure.

You are always in charge of your own care — even during a clinical trial. Be sure you understand:

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Can I stop participating at any time?​

Will leaving the study affect my regular care?​

Will I be told if there’s new information that could affect my decision to stay?​

Who do I contact with questions or concerns during the trial?​

What happens to my medical data — and who has access to it?

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If a study doesn’t fully respect your rights, walk away. You’re not locked in, and no one should ever make you feel otherwise.

Many people are surprised to find they won’t always get study results — or that their care ends abruptly. That’s changing, but it’s still worth asking:

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Will I get a summary of the trial results?​

Will I be told what treatment I received (if it was a blinded study)?​

Will I be monitored for any long-term effects?​

If the treatment works, can I keep using it?​

Will I return to my regular doctor after the study?

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Knowing what comes next helps you plan — and helps you decide whether the experience will be worth your time and trust.

You have every right to take your time, ask more than once, or walk away without joining. A research team that values patients will never rush or pressure you. Instead, they’ll make space for:​

• Clear communication​
• Honest discussion of risks and benefits
• Time to consult with loved ones or your regular doctor
• Support for whatever decision you make

Because good research starts with good respect.